Hypothalamic disorders cause reduced TSH secretion by impairing the production or transport of TRH to the pituitary gland. Hypothyroidism may occur because the pituitary secretes TSH in insufficient quantities, or secretes TSH with an abnormal glycosylation pattern which reduces the biologic activity of TSH 1,2,3 . Treatment with oral TRH restores the biologic activity of TSH, suggesting that deficient hypothalamic TRH release induces both quantitative and qualitative abnormalities of TSH secretion. TSH molecules with reduced biologic activity may retain their immunologic reactivity in TSH immunoassays, explaining the sometimes observed slightly increased values of serum TSH (up to 10 mU/l) in central hypothyroidism 18, 23 .
You need to be careful with EQ and DEC because both may possibly hold a slight bit of water and/or aromatize slightly depending on your genetics. If you have not yet tried either, don’t use them for your first show or an important modeling shoot. Stick with the first four. There are some others but these are the most well known in our community and the most accessible. Tren, primo, anavar, and winstrol do not aromatize at all and hold no water. Of all these drugs, tren is the best for dieting-you will stay strong which will directly affect your ability to hold your hard earned mass. This is because tren is a heavy androgen (though non-aromatizing) as we’ve said before. It will continue to keep your aggression levels high in the gym to be able to do the work that you need to, in order to get shredded. Anavar, primo, and Winnie are good dieting drugs too but are typically harder to find and very expensive. They are also weak drugs. We will discuss options for combining these drugs in future pages as well as dosages and my favorite; how to use testosterone while getting shredded. Please come back soon, I’m trying to find as much time as I can to write.
Once more, an early study done on S-4 provided proof of full muscle regeneration in volunteers with with degenerative disorders without the use of exercise and the minimum dosage of 3mg/kg/day. Changes can be seen anywhere from 1-2 weeks. This was the very first study classified S-4 as CLINICALLY SIGNIFICANT by improving skeletal muscle strength, lean body mass, and a reduction in body fat [Chen et al., 2005; Gao et al., 2005; Kearbey et al., 2007]. Unfortunately, there are always some side effects that arise when using Because S-4 is a ligand by definition, the side effects will never be permanent even at supraphysiological dosages and can be easily avoided through proper dosing.