Before you start this treatment , read the manufacturer's printed information leaflet from inside your pack. The leaflet will give you more information about mesterolone tablets. Take the tablets exactly as your doctor has told you to. To begin with , it is usual to be prescribed 25 mg (one tablet) , to be taken three or four times a day. If you need to continue taking the tablets for more than a few months , your doctor may reduce the number of tablets you need to take each day. Your doctor will tell you what dose is right for you and this will also be printed on the label of the pack to remind you. Swallow the tablet whole with a drink of water. You can take mesterolone before or after meals. Try to take your doses at the same times each day , as this will help you to remember to take them. If you forget to take a dose , you should take it when you remember. However , if when you remember ,
In one randomized, double-blind 4-week trial, 38 dysthymic men were administered 75 mg daily. Itil & Colleagues reported an improvement of symptoms which included anxiety, lack of drive and desire. Next, they administered a high dose (450 mg/day) or placebo in a 6-week randomized trial of 52 men with a mean age of 40 years, suffering from dysthymia , unipolar and bipolar depression . Both the mesterolone and placebo groups improved significantly and there were no statistically significant differences between the two groups. In this series of studies mesterolone lead to a significant decrease in LH and testosterone levels. This is probably as a result of the extremely high dose used. In another, 100 mg mesterolone cipionate was administered twice monthly. With regards to plasma T levels, there was no difference between the treated vs untreated group, and baseline LH levels were minimally affected. [ 2 ]
During the late 1970s, doctors who performed studies on mesterolone concluded that the drug could be used to treat depression in some men. Patients with symptoms of anxiety and low sex drive reported improvement with low doses of the steroid. During the study, higher doses proved helpful to patients with dysthymia and bipolar depression as well. Since this time, newer studies have shown that patients taking a placebo improved at the same rate as patients taking mesterolone, leading medical professionals to believe that better drug options exist.