During conventional pharmacologic dose corticosteroid therapy, ACTH production is inhibited with subsequent suppression of cortisol production by the adrenal cortex. Recovery time for normal HPA activity is variable depending upon the dose and duration of treatment. During this time the patient is vulnerable to any stressful situation. Although it has been shown that there is considerably less adrenal suppression following a single morning dose of prednisolone (10 mg) as opposed to a quarter of that dose administered every six hours, there is evidence that some suppressive effect on adrenal activity may be carried over into the following day when pharmacologic doses are used. Further, it has been shown that a single dose of certain corticosteroids will produce adrenal cortical suppression for two or more days. Other corticoids, including methylprednisolone, hydrocortisone, prednisone, and prednisolone, are considered to be short acting (producing adrenal cortical suppression for 1¼ to 1½ days following a single dose) and thus are recommended for alternate day therapy.
Prednisolone is an adrenocortical steroid used for multiple conditions including endocrine disorders, rheumatic disorders, collagen diseases, skin diseases, allergies, eye diseases, respiratory diseases, blood disorders, cancers, edematous states, gastrointestinal diseases, and nervous system disorders, among others. The brand name of this medication is discontinued, but generic versions may be available. Common side effects of prednisolone include infections, heartburn, trouble sleeping (insomnia), hunger, nausea, headache, dizziness, menstrual period changes, increased sweating, acne, and nervousness.
Antileukotriene agents in the management of asthma
Allergen avoidance in the treatment of asthma and allergic rhinitis
An overview of asthma management
Diagnosis of asthma in adolescents and adults
Evaluation of severe asthma in adolescents and adults
Identifying patients at risk for fatal asthma
Natural history of asthma
Severe asthma phenotypes
Management of acute exacerbations of asthma in adults
Treatment of intermittent and mild persistent asthma in adolescents and adults
Treatment of moderate persistent asthma in adolescents and adults
Treatment of severe asthma in adolescents and adults
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