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As with other NSAIDs, anaphylactoid reactions may occur in patients without prior exposure to diclofenac sodium topical gel. Diclofenac sodium topical gel should not be given to patients with the aspirin triad. This symptom complex typically occurs in asthmatic patients who experience rhinitis with or without nasal polyps, or who exhibit severe, potentially fatal bronchospasm after taking aspirin or other NSAIDs [see Contraindications, Warnings and Precautions]. Emergency help should be sought in cases where an anaphylactoid reaction occurs.
We once thought arthritis was the result of wear and tear – but more recent research shows this isn’t the case. Researchers from Stanford University say arthritis may be the result of chronic, low-grade inflammation. In a nutshell, the immune system releases proteins that damage joints – and these proteins also bind to cartilage-producing cells in the joints, causing them to secrete even more of the damaging proteins. This creates a cascade of chronic, low-grade inflammation in the joint … especially if there’s already arthritis.