The pooled analyses of placebo-controlled studies in children and adolescents with MDD, obsessive compulsive disorder ( OCD ), or other psychiatric disorders included a total of 24 shortterm studies of 9 antidepressant drugs in over 4400 patients. The pooled analyses of placebo controlled studies in adults with MDD or other psychiatric disorders included a total of 295 short-term studies (median duration of 2 months) of 11 antidepressant drugs in over 77,000 patients. There was considerable variation in risk of suicidality among drugs, but a tendency toward an increase in the younger patients for almost all drugs studied. There were differences in absolute risk of suicidality across the different indications, with the highest incidence in MDD. The risk differences (drug vs. placebo), however, were relatively stable within age strata and across indications. These risk differences (drug-placebo difference in the number of cases of suicidality per 1000 patients treated) are provided in Table 1.
People with a BMI greater than 30 may have elevated levels of estrogen in the body due to greater body fat content which may also contribute to infertility. This is known as estrogen dominance. Obesity in men lowers testosterone levels. Chronic low levels of testosterone affect how the testis function, which causes all hormones produced by them, to be out of balance. Research shows elevated levels of estrogen in obese men. The sperm of obese men are often abnormal, this increases the risk for miscarriage and chromosomal defects in a developing embryo. Obese men also often have sexual dysfunction.