On a concluding note, the major difference between steroid and peptide hormones is that the former is lipid-soluble and can diffuse easily into the cell membrane of the target cell to connect with receptors, whereas the latter is water-soluble and connects with receptors at the membrane because it can't diffuse through the membrane. Since peptide hormones bind to receptors at the surface, their effect is faster than steroid hormones. Both these hormones perform vital bodily functions, and any problems in the working of these hormones and their receptors can have a serious repercussion on one's health.
Cells of the zona fasciculata and zona reticularis lack aldosterone synthase (CYP11B2) that converts corticosterone to aldosterone, and thus these tissues produce only the weak mineralocorticoid corticosterone. However, both these zones do contain the CYP17A1 missing in zona glomerulosa and thus produce the major glucocorticoid, cortisol. Zona fasciculata and zona reticularis cells also contain CYP17A1, whose 17,20-lyase activity is responsible for producing the androgens, dehydroepiandrosterone (DHEA) and androstenedione. Thus, fasciculata and reticularis cells can make corticosteroids and the adrenal androgens, but not aldosterone.